G12 Signaling through c-Jun NH2-Terminal Kinase Promotes Breast Cancer Cell Invasion
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منابع مشابه
G12 Signaling through c-Jun NH2-Terminal Kinase Promotes Breast Cancer Cell Invasion
Signaling through the heterotrimeric G protein, G12, via Rho induces a striking increase in breast cancer cell invasion. In this study, evidence is provided that the c-Jun NH(2)-terminal kinase (JNK) is a key downstream effector of G12 on this pathway. Expression of constitutively-active Gα12 or activation of G12 signaling by thrombin leads to increased JNK and c-Jun phosphorylation. Pharmacolo...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0026085